Mesenchymal Stem Cells Seeded Decellularized Tendon Scaffold for Tissue Engineering

Tendon is a collagenous tissue to connect bone and muscle. Healing of damaged/injured tendon is the primary clinical challenge in musculoskeletal regeneration because they often react poorly to treatment. Tissue engineering (a triad strategy of scaffolds, cells and growth factors) may have the potential to improve the quality of tendon tissue healing under such impaired situations. Tendon tissue engineering aims to synthesize graft alternatives to repair the injured tendon. Biological scaffolds derived from decellularized tissue may be a better option as their biomechanical properties are similar to the native tissue. This review is designed to provide background information on the current challenges in curing torn/worn out the tendon and the clinical relevance of decellularized scaffolds for such applications.

Automated summary

Tendon, a collagenous tissue connecting bone and muscle, poses a primary clinical challenge in musculoskeletal regeneration due to poor treatment response. Tissue engineering, utilizing scaffolds, cells, and growth factors, shows potential in improving tendon tissue healing under impaired conditions. Biological scaffolds derived from decellularized tissue may offer better biomechanical properties for repairing injured tendons.