Journal
CELL REPORTS
Volume 32, Issue 6, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.celrep.2020.107992
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Funding
- Allen Discovery Center at Stanford on Systems Modeling of Infection
- Gatsby Charitable Foundation [GAT3395/PR4B]
- National Science Foundation [PHYS1066293]
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High-throughput imaging has led to an explosion of observations about cell-size homeostasis across the kingdoms of life. Among bacteria, adder behavior-in which a constant size increment appears to be added during each cell cycle-is ubiquitous, while various eukaryotes show other size-homeostasis behaviors. Since interactions between cell-cycle progression and growth ultimately determine such behaviors, we developed a general model of cell-cycle regulation. Our analyses reveal a range of scenarios that are plausible but fail to regulate cell size, indicating that mechanisms of cell-cycle regulation are stringently limited by size-control requirements, and possibly why certain cell-cycle features are strongly conserved. Cell-cycle features can play unintuitive roles in altering size-homeostasis behaviors: noisy regulator production can enhance adder behavior. while Whi5-like inhibitor dilutors respond sensitively to perturbations to G2/M control and noisy G1/S checkpoints. Our model thus provides holistic insights into the mechanistic implications of size-homeostasis experimental measurements.
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