Wavelength-Selective Light-Controlled Stepwise Photolysis from Single Gold Nanoparticles

Light-controlled sequential photolysis from a single nanoparticle is a challenge for controlled release. A wavelength-selective sequential photolysis from single gold nanoparticles is reported for the first time. In particular, it is also demonstrated that such nanoparticle can be used to sequentially release two payloads in living cells. In principle, this system can be extended to sequential release of multiple different types of payloads by rational design of diverse photocleavable linkers. It is expected that this work can provide a new tool for better orderly controlling cellular events that request high spatiotemporal manners.

Automated summary

This study reports the first wavelength-selective sequential photolysis from single gold nanoparticles, demonstrating their ability to sequentially release multiple payloads in living cells. By rational design of diverse photocleavable linkers, this system can potentially be extended to sequential release of various types of payloads. The work provides a new tool for better orderly controlling cellular events that require high spatiotemporal precision.