Journal
ADVANCED HEALTHCARE MATERIALS
Volume 9, Issue 24, Pages -Publisher
WILEY
DOI: 10.1002/adhm.202000734
Keywords
additive manufacturing; biofabrication; decellularization; tissue engineering
Funding
- National Science Foundation [DMR-1714882]
- Center for Engineering MechanoBiology (CEMB)
- NSF Science and Technology Center [CMMI: 15-48571]
- MTF Biologics
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3D bioprinting is an emerging technology to fabricate tissues and organs by precisely positioning cells into 3D structures using printable cell-laden formulations known as bioinks. Various bioinks are utilized in 3D bioprinting applications; however, developing the perfect bioink to fabricate constructs with biomimetic microenvironment and mechanical properties that are similar to native tissues is a challenging task. In recent years, decellularized extracellular matrix (dECM)-based bioinks have received an increasing attention in 3D bioprinting applications, since they are derived from native tissues and possess unique, complex tissue-specific biochemical properties. This review focuses on designing dECM-based bioinks for tissue and organ bioprinting, including commonly used decellularization and decellularized tissue characterization methods, bioink formulation and characterization, applications of dECM-based bioinks, and most recent advancements in dECM-based bioink design.
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