Journal
ADVANCED HEALTHCARE MATERIALS
Volume 10, Issue 5, Pages -Publisher
WILEY
DOI: 10.1002/adhm.202000912
Keywords
CT imaging; functional CT contrast nanoagents (FCTNAs); stimuli-responsive nanoparticles; tumor microenvironments
Funding
- National Funds for Distinguished Young Scientists [51725202]
- Key Project of Shanghai Science and Technology Commission [19JC1412000, 19JC1412002]
- National Natural Science Foundation of China [51872094]
- National Key R&D Program of China [2018YFA0107900]
- Collaborative Innovation Center of Technology and Equipment for Biological Diagnosis and Therapy in Universities of Shandong, the Shanghai Key Laboratory of Magnetic Resonance [SKMR2020B01]
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Understanding the tumor microenvironment is crucial for effective tumor treatment, and using functional CT contrast nanoagents can help accurately diagnose TME and guide personalized treatment.
Understanding the detailed tumor microenvironment (TME) is essential to achieve effective treatment of tumor, because TME has an extremely profound influence on the occurrence, development, invasion, and metastasis of tumor. It is of great significance to realize accurate diagnosis of the TME by using functional computed tomography (CT) contrast nanoagents (FCTNAs). Here, an overview of FCTNAs that respond to the overexpressed receptors, acidic microenvironment, overexpressed glutathione and enzymes, and hypoxia in tumor is provided, and also prospects the advance of novel spectral CT technique to detect the TME precisely. Utilizing FCTNAs is expected to achieve accurate monitoring of the TME and further provide guidance for the effective personalized tumor treatment in clinic.
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