Journal
COGNITIVE NEURODYNAMICS
Volume 10, Issue 6, Pages 563-571Publisher
SPRINGER
DOI: 10.1007/s11571-016-9401-5
Keywords
Glucose; Energy metabolism; ATP; Ion channels
Categories
Funding
- National Natural Science Foundation of China [11232005, 11472104]
Ask authors/readers for more resources
The glucose-excited neurons in brain can sense blood glucose levels and reflect different firing states, which are mainly associated with regulation of blood glucose and energy demand in the brain. In this paper, a new model of glucose-excited neuron in hypothalamus is proposed. The firing properties and energy consumption of this type of neuron under conditions of different glucose levels are simulated and analyzed. The results show that the firing rate and firing duration of the neuron both increase with increasing extracellular glucose levels, but the maximum energy power for an AP is reduced. Further study suggests that the neuron firstly absorbs energy substrates (e.g. glucose) from the blood to prepare for the high energy demand of high-frequency spikes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available