Effect of genetic variation in Notch regulator DTX1 on SCLC prognosis compared with the effect on NSCLC prongosis

Deltex-1 (DTX1)is a negative regulator of the Notch signaling pathway. Here, we investigated the clinical effect ofDTX1rs1732786A > G, which is associated with better prognosis in patients with early-stage non-small cell lung cancer (NSCLC), in 261 patients with small cell lung cancer (SCLC).DTX1rs1732786A > G was associated with a significantly worse chemotherapy response and lower overall survival in the codominant model (odds ratio = 0.42, 95% confidence interval [CI]: 0.26-0.66,P= 2 x 10(-4); hazard ratio = 1.47, 95% CI: 1.17-1.84,P= 0.001, respectively). An in vitro luciferase assay was performed, and the 1732786G allele demonstrated significantly higher promoter activity than the 1732786A allele (P= 2 x 10(-7)). In summary,DTX1rs1732786A > G was associated with poor prognosis in patients with SCLC as opposed to patients with NSCLC. Key pointsSignificant findings of the study DTX1rs1732786A > G was associated with better prognosis in patients with early-stage non-small cell lung cancer (NSCLC) in our previous study. What this study adds DTX1rs1732786A > G was associated with a significantly worse chemotherapy response and lower overall survival in small cell lung cancer (SCLC).