Journal
SCIENTIFIC REPORTS
Volume 10, Issue 1, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-020-68802-9
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Funding
- Spanish Ministry of Science, Innovation and Universities (MCNU) [SAF2016-78370-R, CB16/11/00399, RD16/0011/0021]
- Fundacion BBVA [BIO14_298]
- Fundacion La Marato [20153431]
- CardioNeT from the European Commission [28600]
- MCIU [MAT2016-76507-R]
- Comunidad de Madrid [S2018/NMT-4443]
- Tec4Bio
- European Research Council (ERC-AdG) [340177]
- European Regional Development Fund
- Instituto de Salud Carlos III (ISCIII)
- MCNU
- Pro CNIC Foundation
- Severo Ochoa Centre of Excellence [SEV-2015-0505]
- European Research Council (ERC) [340177] Funding Source: European Research Council (ERC)
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Caveolin-1 is the main structural protein of caveolae, small membrane invaginations involved in signal transduction and mechanoprotection. Here, we generated cav1-KO zebrafish lacking Cav1 and caveolae, and investigated the impact of this loss on adult heart function and response to cryoinjury. We found that cardiac function was impaired in adult cav1-KO fish, which showed a significantly decreased ejection fraction and heart rate. Using atomic force microscopy, we detected an increase in the stiffness of epicardial cells and cells of the cortical zone lacking Cav1/caveolae. This loss of cardiac elasticity might explain the decreased cardiac contraction and function. Surprisingly, cav1-KO mutants were able to regenerate their heart after a cryoinjury but showed a transient decrease in cardiomyocyte proliferation.
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