Journal
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
Volume 15, Issue 10, Pages 1231-1239Publisher
BENTHAM SCIENCE PUBL
DOI: 10.2174/1871527315666160919101349
Keywords
Endophytes; inflammation; neuro-hydrolases; oxidative stress; protein aggregation; neurodegenerative diseases
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Funding
- CSIR [BSC-108, BSC-106]
- Ramalingaswamy Fellowship of Department of Biotechnology
- CSIR
- University Grants Commission
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Neurodegeneration is progressive loss of functional and structural integrity of the central nervous system. Neurodegenerative disorders are yet without any reliable therapy because the neurons of the central nervous system have limited ability to regenerate. Current therapeutic approaches rely mainly on abrogation of symptoms and leave the dying neurons to their fate. Protective and/or rescuing treatments need to be explored fully to suppress neuronal death that will automatically alleviate the symptoms. Adequate precedent exists in literature regarding the neuroprotective activity of endophytes. Endophytes are a class of microorganisms which colonize healthy plant tissues without causing any apparent harm to the host. Chemical moieties from known endophytes have been used against many disease models including neurodegenerative diseases. There is great hope that novel bioactive molecules from newer endophytes can impede pathogenic mechanisms and progression of many diseases. In this review, we will discuss promising pharmacological or clinical relevance of endophytes against various neurodegenerative diseases.
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