Journal
MATERIALS
Volume 13, Issue 16, Pages -Publisher
MDPI
DOI: 10.3390/ma13163580
Keywords
silk fibroin; nanofibers; electrospinning; casein; diclofenac; drug delivery system
Categories
Funding
- Slovak Grant Agency for Science [APVV 18-0420, 2/0161/17]
- Polish-Slovak joint research project Predictive study under composting conditions of bioactive materials obtained by electrospinning (2019-2021)
- Research & Innovation Operational Programme - ERDF [313021T081]
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Silk fibroin is a biocompatible, non-toxic, mechanically robust protein, and it is commonly used and studied as a material for biomedical applications. Silk fibroin also gained particular interest as a drug carrier vehicle, and numerous silk formats have been investigated for this purpose. Herein, we have prepared electrospun nanofibers from pure silk fibroin and blended silk fibroin/casein, followed by the incorporation of an anti-inflammatory drug, diclofenac. Casein serves as an excipient in pharmaceutical products and has a positive effect on the gradual release of drugs. The characteristics of the investigated composites were estimated by scanning electron microscope, transmission electron microscope, thermogravimetric analysis, and a lifetime of diclofenac by electron paramagnetic resonance analysis. The cumulative release in vitro of diclofenac sodium salt, together with the antiproliferative effect of diclofenac sodium salt-loaded silk nanofibers against the growth of two cancer cell lines, are presented and discussed.
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