Journal
BIOMEDICAL OPTICS EXPRESS
Volume 11, Issue 8, Pages 4520-4535Publisher
OPTICAL SOC AMER
DOI: 10.1364/BOE.393906
Keywords
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Funding
- European Commission [MERLIN-H2020 ICT 780989]
- Austrian Science Fund [SFB-F 68-Tomography]
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Using adaptive optics optical coherence tomography, human photoreceptors and retinal pigment epithelium (RPE) cells are typically visualized on a small field of view of x1 degrees to 2 degrees. In addition, volume averaging is required for visualizing the RPE cell mosaic. To increase the imaging area, we introduce a lens based spectral domain AO-OCT system that shows low aberrations within an extended imaging area of 4 degrees x 4 degrees while maintaining a high (theoretical) transverse resolution (at >7mm pupil diameter) in the order of 2 mu m. A new concept for wavefront sensing is introduced that uses light mainly originating from the RPE layer and yields images of the RPE cell mosaic in a single volume acquisition. The capability of the instrument for in vivo imaging is demonstrated by visualizing various cell structures within the posterior retinal layers over an extended field of view. Published by The Optical Society under the terms of the Creative Commons Attribution 4.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI.
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