Journal
CLINICS IN LIVER DISEASE
Volume 20, Issue 2, Pages 263-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cld.2015.10.012
Keywords
Nonalcoholic fatty liver disease; Fatty liver; Steatohepatitis; Fibrosis; Liver cirrhosis; Hepatocellular carcinoma; Gut microbiota
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Recent progress has allowed a more comprehensive study of the gut microbiota. Gut microbiota helps in health maintenance and gut dysbiosis associates with chronic metabolic diseases. Modulation of short-chain fatty acids and choline bioavailability, lipoprotein lipase induction, alteration of bile acid profile, endogenous alcohol production, or liver inflammation secondary to endotoxemia result from gut dysbiosis. Modulation of the gut microbiota by pre/probiotics gives promising results in animals, but needs to be evaluated in humans before use in clinical practice. Gut microbiota adds complexity to the pathophysiology of nonalcoholic fatty liver disease but represents an opportunity to discover new therapeutic targets.
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