Journal
CLINICS IN LIVER DISEASE
Volume 20, Issue 1, Pages 79-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cld.2015.08.014
Keywords
Primary sclerosing cholangitis; Carcinoma; Dysplasia; Cholangiocarcinoma; Inflammatory bowel disease; Surveillance; Brush cytology
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Primary sclerosing cholangitis (psq is a chronic, progressive disease characterized by inflammatory and fibrosing strictures of the biliary tree. PSC is associated with a high lifetime risk of hepatobiliary and colorectal cancers. The nature of the carcinogenic process in PSC is not well established. The lack of diagnostic methods for early detection and the limited therapeutic options for cholangiocarcinoma constitute a major challenge in the current handling of PSC patients. The article reviews the risk for cancer development in PSC and discusses surveillance strategies for PSC-associated cancers.
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