Journal
CLINICS IN LIVER DISEASE
Volume 20, Issue 3, Pages 445-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cld.2016.02.004
Keywords
Sterile necrosis; Corticosteroids; Alcoholic liver disease; Alcoholic hepatitis; Intestinal permeability; Microbiome
Categories
Funding
- NIAAA NIH HHS [U01 AA021788, R01 AA021171, R37 AA021171] Funding Source: Medline
- NIDDK NIH HHS [T32 DK007202] Funding Source: Medline
Ask authors/readers for more resources
Alcoholic liver disease includes a broad clinical-histological spectrum from simple steatosis, cirrhosis, acute alcoholic hepatitis with or without cirrhosis to hepatocellular carcinoma as a complication of cirrhosis. The pathogenesis of alcoholic liver disease can be conceptually divided into (1) ethanol-mediated liver injury, (2) inflammatory immune response to injury, (3) intestinal permeability and microbiome changes. Corticosteroids may improve outcomes, but this is controversial and probably only impacts short-term survival. New pathophysiology-based therapies are under study, including antibiotics, caspase inhibition, interleukin-22, anakinra, FXR agonist and others. These studies provide hope for better future outcomes for this difficult disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available