Journal
NATURE COMMUNICATIONS
Volume 11, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-020-17588-5
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Funding
- state of Mecklenburg-Vorpommern
- BMBF
- Generalitat Valenciana
- la Caixa Foundation [100010434]
- Ermenegildo Zegna Founder's Scholarship
- [LCF/BQ/PI18/11630023]
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Catalytic hydrogenation of amides is of great interest for chemists working in organic synthesis, as the resulting amines are widely featured in natural products, drugs, agrochemicals, dyes, etc. Compared to traditional reduction of amides using (over)stoichiometric reductants, the direct hydrogenation of amides using molecular hydrogen represents a greener approach. Furthermore, amide hydrogenation is a highly versatile transformation, since not only higher amines (obtained by C-O cleavage), but also lower amines and alcohols, or amino alcohols (obtained by C-N cleavage) can be selectively accessed by fine tuning of reaction conditions. This review describes the most recent advances in the area of amide hydrogenation using H-2 exclusively and molecularly defined homogeneous as well as nano-structured heterogeneous catalysts, with a special focus on catalyst development and synthetic applications. Catalytic hydrogenation of amides is a pivotal chemical transformation for both research labs and chemical production in industry. Here, the authors comprehensively review this topic by including state-of-art homogeneous and heterogeneous catalysts that can hydrogenate amides and related compounds.
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