Journal
ONCOLOGY LETTERS
Volume 20, Issue 3, Pages 2537-2556Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2020.11835
Keywords
microRNAs; biomarkers; oncogenes; tumor suppressors; carcinogenesis
Categories
Funding
- National Natural Science Foundation of China [31770774]
- Provincial Major Project of Basic or Applied Research in Natural Science, Guangdong Provincial Education Department [2016KZDXM038]
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Cancer causes most of the mortality and morbidity worldwide, with a significant increase in incidence during recent years. MicroRNAs (miRNAs/miRs) are non-coding small RNAs capable of regulating gene expression. They regulate crucial cellular processes, including proliferation, differentiation, metastasis and apoptosis. Therefore, abnormal miRNA expression is associated with multiple diseases, including cancer. There are two types of cancer-associated miRNAs, oncogenic and tumor suppressor miRNAs, depending on their roles and expression patterns in cancer. Accordingly, miRNAs are considered to be targets for cancer prevention and treatment. miR-33a controls cellular cholesterol uptake and synthesis, which are both closely associated with carcinogenesis. The present review thoroughly describes the roles of miR-33a in more than a dozen types of cancer and the underlying mechanisms. Accordingly, the present review may serve as a guide for researchers studying the involvement of miR-33a in diverse cancer settings.
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