Journal
EPIGENOMICS
Volume 12, Issue 9, Pages 801-809Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/epi-2019-0358
Keywords
ALKBH5; cancer; drug resistance; FTO; m6A; METTL14; METTL3; RNA methylation; WTAP
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Aim: As one of the early adaptive mechanisms by which cells respond to environmental changes, RNA modification appears to be a very promising target for cancer treatment. Results: RNA modifications are currently a hot topic in epigenetic research. Emerging experimental studies show that expression alterations of multiple m6A enzymes, including demethylase FTO, methyltransferase METTL3 and WTAP, mediate the development of resistance of cancer cells to various treatments. A set of small molecular chemical drugs targeted to these m6A enzymes are under development. Intervention of RNA m6A methylation is a possible therapeutic strategy to overcome drug resistance. Conclusions: RNA m6A methylation may play a crucial role in drug resistance development and intervention in cancer cells.
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