Journal
CLINICS IN DERMATOLOGY
Volume 34, Issue 5, Pages 548-555Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.clindermatol.2016.05.004
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Funding
- South-Eastern Norway Regional Health Authority
- Oslo University Hospital
- Bio-Tech Pharmacal, Inc. (Fayetteville, AR)
- Vitamin D Society (Woodstock, ON, Canada)
- Vitamin D Council (San Luis Obispo, CA)
- UV Foundation (McLean, VA)
- Sunlight Research Forum (Veldhoven)
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The skin is the site for the photosynthesis of vitamin D and is a target tissue for the active metabolite of vitamin D. An increasing body of evidence indicates that vitamin D produced during phototherapy may be responsible for the positive effects observed during treatment of some skin diseases. Topical or oral application of vitamin D derivatives are used alone or with phototherapy. This paper reviews what is known about the use of phototherapy to enhance vitamin D levels, the use of vitamin D analogues with phototherapy, the efficacy of combination therapies, and controversies regarding some of the outcomes. Vitamin D can play a beneficial role in treating psoriasis, even though the exact role of vitamin D in the pathogenesis and severity of psoriasis remains unclear. The role of vitamin D in vitiligo, atopic dermatitis, polymorphic light eruption, and mycosis fungoides must be further investigated. (C) 2016 Elsevier Inc. All rights reserved.
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