Journal
ACS MEDICINAL CHEMISTRY LETTERS
Volume 11, Issue 7, Pages 1361-1366Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.0c00316
Keywords
Prodrug; Covid-19; remdesivir; drug delivery; metabolism
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Funding
- American Cancer Society [RSG-15-145-01-CDD]
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While remdesivir has garnered much hope for its moderate anti-Covid-19 effects, its parent nucleoside, GS-441524, has been overlooked. Pharmacokinetic analysis of remdesivir evidences premature serum hydrolysis to GS-441524; GS-441524 is the predominant metabolite reaching the lungs. With its synthetic simplicity and in vivo efficacy in the veterinary setting, we contend that GS-441524 is superior to remdesivir for Covid-19 treatment.
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