4.5 Article

Difference in Metabolomic Response to Exercise between Patients with and without Hypertrophic Cardiomyopathy

Journal

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
Volume 14, Issue 2, Pages 246-255

Publisher

SPRINGER
DOI: 10.1007/s12265-020-10051-2

Keywords

Metabolomics; Hypertrophic cardiomyopathy; Exercise

Funding

  1. American Heart Association
  2. Korea Institute of Oriental Medicine
  3. Columbia University Medical Center Irving Institute for Clinical & Translational Research Precision Medicine Pilot Award

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This study compared the metabolomic profiles of patients with hypertrophic cardiomyopathy (HCM) and control groups during rest and exercise, revealing significant differences in metabolic pathways during exercise stress for the HCM patients.
It is unclear how hypertrophic cardiomyopathy (HCM) affects cardiac metabolic pathways at rest and with exercise. This case-control study compared 15 cases with HCM to 2 control groups without HCM. Metabolomic profiling of 210 metabolites was carried out at rest and at peak exercise. The 50 most discriminant metabolites differentially regulated during exercise were selected using partial least squares discriminant analysis. Pathway enrichment analysis was also performed. At rest, no significant difference was observed in metabolomic profiling of HCM cases as compared to controls. By contrast, there were significant differences in metabolomic profiling in response to exercise (p < 0.05) in the following metabolic pathways: the aminoacyl-tRNA biosynthesis pathway; the nitrogen metabolism pathway; the glycine, serine, and threonine metabolism pathway; and the arginine and proline metabolism pathway. The present study demonstrates differential regulation of several metabolic pathways in patients with HCM in the setting of exercise stress.

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