Journal
CLINICS IN CHEST MEDICINE
Volume 37, Issue 1, Pages 147-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccm.2015.11.003
Keywords
Chronic obstructive pulmonary disease; Cystic fibrosis transmembrane conductance regulator; Chronic bronchitis; Mucociliary clearance
Categories
Funding
- NIH [R01 HL105487, P30 DK072482, 5UL1 RR025777]
- Cystic Fibrosis Foundation [CLANCY09Y0, R464-CF]
- American Lung Association [RG-305752]
- Flight Attendants Medical Research Association [YFA130008]
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Chronic obstructive pulmonary disease (COPD) is a major public health problem. No therapies alter the natural history of the disease. Chronic bronchitis is perhaps the most clinically troublesome phenotype. Emerging data strongly suggest that cigarette smoke and its components can lead to acquired cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction. Findings in vitro, in animal models, and in smokers with and without COPD also show acquired CFTR dysfunction, which is associated with chronic bronchitis. This abnormality is also present in extrapulmonary organs, suggesting that CFTR dysfunction may contribute to smoking-related systemic diseases.
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