Journal
JOURNAL OF FUNCTIONAL FOODS
Volume 69, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jff.2020.103953
Keywords
Constipation; Acylated starches; Short-chain fatty acids; Faecal microbiota
Categories
Funding
- National Natural Science Foundation of China [81800469, 31671839]
- Natural Science Foundation of Jiangsu Province [BK20180613]
- China Postdoctoral Science Foundation [2018 M642164]
- Postdoctoral Science Foundation of Jiangsu Province [2018K090C]
- National Natural Science Foundation of China Key Program [31530056]
- Fundamental Research Funds for the Central Universities [JUSRP51501]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- national first-class discipline program of Food Science and Technology [JUFSTR20180102]
- Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province
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Constipation is a disorder that affects people of all ages. Previous study showed Bifidobacterium spp. altered the faecal concentrations of short-chain fatty acids (SCFAs) while relieving constipation. Therefore, we speculated SCFAs might relieve constipation. We evaluated constipation-related indicators, SCFA levels and the faecal microbiota of constipated mice that were fed acylated starches derived from specific SCFAs for 1 month. It confirmed application of acylated starches resolved the issue of SCFAs absorption in small intestine by measuring the concentration of different SCFA in various tissues. Acetylated starch relieved constipation by increasing acetic acid-producing bacteria that were correlated positively with the small intestinal transit rate and water content of faeces, while butylated starch relieved constipation by increasing butyric acid-producing bacteria that were correlated negatively with the time to the first black stool defecation. These results indicated acetic acid and butyric acid play different roles in relieving constipation.
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