Journal
ONCOTARGETS AND THERAPY
Volume 13, Issue -, Pages 7699-7717Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S267140
Keywords
endocrine; cancers; lncRNA; SNHG
Categories
Funding
- National Natural Science Foundation of China [81902726]
- China Postdoctoral Science Foundation [2018M641739]
- Natural Science Foundation of Liaoning Province [20180530090]
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Long non-coding RNAs (lncRNAs) are emerging regulators of a diverse range of biological processes through various mechanisms. Genome-wide association studies of tumor samples have identified several lncRNAs, which act as either oncogenes or tumor suppressors in various types of cancers. Small nucleolar RNAs (snoRNAs) are predominantly found in the nucleolus and function as guide RNAs for the processing of transcription. As the host genes of snoRNAs, lncRNA small nucleolar RNA host genes (SNHGs) have been shown to be abnormally expressed in multiple cancers and can participate in cell proliferation, tumor progression, metastasis, and chemoresistance. Here, we review the biological functions and emerging mechanisms of SNHGs involved in the development and progression of endocrine-related cancers including thyroid cancer, breast cancer, pancreatic cancer, ovarian cancer and prostate cancer.
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