Journal
FRONTIERS IN NEURAL CIRCUITS
Volume 14, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fncir.2020.00037
Keywords
nucleus accumbens; depression; addiction; comorbidity; deep brain stimulation; dopamine
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Funding
- National Natural Science Foundations of China [81560231, 81860251]
- Yanbian University Training Program of Innovation and Entrepreneurship for Undergraduates [YDCXCY2019002]
- State Key Laboratory of Medical Neurobiology
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The comorbidity of depression and addiction has become a serious public health issue, and the relationship between these two disorders and their potential mechanisms has attracted extensive attention. Numerous studies have suggested that depression and addiction share common mechanisms and anatomical pathways. The nucleus accumbens (NAc) has long been considered a key brain region for regulating many behaviors, especially those related to depression and addiction. In this review article, we focus on the association between addiction and depression, highlighting the potential mediating role of the NAc in this comorbidityviathe regulation of changes in the neural circuits and molecular signaling. To clarify the mechanisms underlying this association, we summarize evidence from overlapping reward neurocircuitry, the resemblance of cellular and molecular mechanisms, and common treatments. Understanding the interplay between these disorders should help guide clinical comorbidity prevention and the search for a new target for comorbidity treatment.
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