Journal
JOURNAL OF BREATH RESEARCH
Volume 14, Issue 4, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1752-7163/abaf07
Keywords
cavity-enhanced optical techniques; mid-infrared; optical diagnostics
Categories
Funding
- Deutsche Forschungsgemeinschaft (DFG) [GRK2203-PULMOSENS]
- European Union [824986]
- H2020 Societal Challenges Programme [824986] Funding Source: H2020 Societal Challenges Programme
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Cavity-enhanced absorption spectroscopies (CEAS) have gained importance in a wide range of applications in molecular spectroscopy. The development of optical sensors based on the CEAS techniques coupled with the continuous wave or pulsed laser sources operating in the mid-infrared or near-infrared spectral regime uniquely offers molecularly selective and ultra-sensitive detection of trace species in complex matrices including exhaled human breath. In this review, we discussed recent applications of CEAS for analyzing trace constituents within the exhaled breath matrix facilitating the non-invasive assessment of human health status. Next to a brief discussion on the mechanisms of formation of trace components found in the exhaled breath matrix related to particular disease states, existing challenges in CEAS and future development towards non-invasive clinical diagnostics will be discussed.
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