Journal
VIRUSES-BASEL
Volume 12, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/v12080838
Keywords
HIV-1; A6; integrase; INSTI; L74I; polymorphisms; genetic barrier; founder effect; phylogenetics; Russia
Categories
Funding
- Russian Science Foundation [18-75-10096]
- Russian Science Foundation [18-75-10096] Funding Source: Russian Science Foundation
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The increasing use of the integrase strand transfer inhibitor (INSTI) class for the treatment of HIV-infection has pointed to the importance of analyzing the features of HIV-1 subtypes for an improved understanding of viral genetic variability in the occurrence of drug resistance (DR). In this study, we have described the prevalence of INSTI DR in a Russian cohort and the genetic features of HIV-1 integrase sub-subtype A6. We included 408 HIV infected patients who were not exposed to INSTI. Drug resistance mutations (DRMs) were detected among 1.3% of ART-naive patients and among 2.7% of INSTI-naive patients. The prevalence of 12 polymorphic mutations was significantly different between sub-subtypes A6 and A1. Analysis of the genetic barriers determined two positions in which subtype A (A1 and A6) showed a higher genetic barrier (G140C and V151I) compared with subtype B, and one position in which subtypes A1 and B displayed a higher genetic barrier (L74M and L74I) than sub-subtype A6. Additionally, we confirmed that the L74I mutation was selected at the early stage of the epidemic and subsequently spread as a founder effect in Russia. Our data have added to the overall understanding of the genetic features of sub-subtype A6 in the context of drug resistance.
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