Journal
CLINICAL SCIENCE
Volume 130, Issue 14, Pages 1137-1146Publisher
PORTLAND PRESS LTD
DOI: 10.1042/CS20160046
Keywords
miRNA; NMDA receptor; psychiatric disorders; synaptic plasticity
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Funding
- Intramural NIH HHS [Z01 MH002881-02] Funding Source: Medline
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The identification and functional delineation of miRNAs (a class of small non-coding RNAs) have added a new layer of complexity to our understanding of the molecular mechanisms underlying synaptic plasticity. Genome-wide association studies in conjunction with investigations in cellular and animal models, moreover, provide evidence that miRNAs are involved in psychiatric disorders. In the present review, we examine the current knowledge about the roles played by miRNAs in NMDA (N-methyl-D-aspartate) receptor-dependent synaptic plasticity and psychiatric disorders.
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