Journal
ULTRASOUND IN MEDICINE AND BIOLOGY
Volume 46, Issue 8, Pages 1854-1864Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ultrasmedbio.2020.03.025
Keywords
Elastography; Liver fibrosis; Point shear wave elastography; Primary sclerosing cholangitis; Shear wave elastography; Transient elastography; Ultrasound
Funding
- University of Bergen
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The aim of the study described here was to characterize three different liver elastography methods in primary sclerosing cholangitis (PSC) patients, for the first time exploring 2-D shear wave elastography (2-D-SWE) in PSC patients and its putative advantages over point shear wave elastography (pSWE). Sixty-six adult PSC patients (51 males, 77%) underwent liver elastography: Transient elastography (TE), pSWE and 2-D-SWE were applied head-to-head after B-mode ultrasonography and blood tests. Liver stiffness measurements (LSMs) by pSWE yielded lower values than those by TE; 2-D-SWE had less steep slope but was overall not significantly different from TE. Correlation between LSMs by pSWE and TE was excellent (intraclass correlation coefficient = 0.92); correlation for 2-D-SWE with either pSWE or TE was moderate but improved with exclusion of overweight individuals. LSMs correlated with the Enhanced Liver Fibrosis test (ELF) across all scanner systems. Our study indicates that LSM by different systems is feasible in PSC patients and that 2-D-SWE tends to underestimate stiffness compared with TE. (E-mail addresses: abmjelle@gmail.com, adnj@helse-bergen.no) (c) 2020 The Author(s). Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine & Biology.
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