Journal
CLINICAL SCIENCE
Volume 130, Issue 4, Pages 221-238Publisher
PORTLAND PRESS LTD
DOI: 10.1042/CS20150350
Keywords
cognitive impairment; renin-angiotensin system; retinopathy; stroke; traumatic brain injury
Categories
Funding
- Veterans Affairs Merit Review [BX000891, R01-NS063965]
- Jowdy and Distinguished Research Professorship [R01-EY-022408]
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As our knowledge expands, it is now clear that the renin-angiotensin (Ang) system (RAS) mediates functions other than regulating blood pressure (BP). The RAS plays a central role in the pathophysiology of different neurovascular unit disorders including stroke and retinopathy. Moreover, the beneficial actions of RAS modulation in brain and retina have been documented in experimental research, but not yet exploited clinically. The RAS is a complex system with distinct yet interconnected components. Understanding the different RAS components and their functions under brain and retinal pathological conditions is crucial to reap their benefits. The aim of the present review is to provide an experimental and clinical update on the role of RAS in the pathophysiology and treatment of stroke and retinopathy. Combining the evidence from both these disorders allows a unique opportunity to move both fields forward.
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