Journal
TRENDS IN NEUROSCIENCES
Volume 43, Issue 10, Pages 780-794Publisher
CELL PRESS
DOI: 10.1016/j.tins.2020.07.004
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Funding
- NIH [R01 NS08539, R01 NS101321, R01 AT010171, R01 AR074795]
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Chronic pain remains challenging to both diagnose and treat. These challenges, in part, arise from limited systems-level understanding of the basic mechanisms that process nociceptive information and ultimately instantiate a subjectively available experience of pain. Here, I provide a framework, the distributed nociceptive system, for understanding nociceptive mechanisms at a systems level by integrating the concepts of neural population coding with distributed processing. Within this framework, wide-spread engagement of populations of neurons produces representations of nociceptive information that are highly resilient to disruption. The distributed nociceptive system provides a foundation for understanding complex spatial aspects of chronic pain and provides an impetus for nonpharmacological cognitive and physical therapies that can effectively target the highly distributed system that gives rise to an experience of pain.
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