Molecular Mechanisms of Intercellular Dissemination of Bacterial Pathogens

Several intracellular bacterial pathogens, including Listeria monocytogenes, Shigella flexerni, and Rickettsia spp. use an actin-based motility process to spread in mammalian cell monolayers. Cell-to-cell spread is mediated by protrusive structures that contain bacteria encased in the host cell plasma membrane. These protrusions, which form in infected host cells, are internalized by neighboring cells. In this review, we summarize key findings on cell-to-cell spread, focusing on recent work on mechanisms of protrusion formation and internalization. We also discuss the dynamic behavior of bacterial populations during spread, and highlight recent findings showing that intercellular spread by an extracellular bacterial pathogen.

Automated summary

The review summarizes the mechanisms of cell-to-cell spread by intracellular bacterial pathogens utilizing actin-based motility, with a focus on protrusion formation and internalization. It also examines the dynamic behavior of bacterial populations during spread and highlights recent findings of intercellular spread by an extracellular bacterial pathogen.