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Golgi Apparatus: An Emerging Platform for Innate Immunity

Journal

TRENDS IN CELL BIOLOGY
Volume 30, Issue 6, Pages 467-477

Publisher

CELL PRESS
DOI: 10.1016/j.tcb.2020.02.008

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Funding

  1. National Natural Science Foundation of China [31700777]
  2. China Postdoctoral Science Foundation [BH2070000094]
  3. First Affiliated Hospital of Bengbu Medical College Science Fund for Outstanding Young Scholars [2019byyfyyq05]
  4. Fundamental Research Funds for the Central Universities [WK2070000149, WK2070080004]
  5. New Medicine Fund of University of Science and Technology of China [WK2070000170]

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The Golgi apparatus serves as a receiving station where proteins from the endoplasmic reticulum (ER) are further processed before being sent to other cellular compartments. In addition to its well-appreciated roles in vesicular trafficking and protein/lipid secretion, recent studies have demonstrated that the Golgi acts as a signaling platform to facilitate multiple innate immune pathways. Moreover, the membranous networks that connect the Golgi with the ER, mitochondria, endosomes, and autophagosomes provide convenient access to innate immune signal transduction and subsequent effector responses. Here, we review the emerging knowledge about the roles of the Golgi in the initiation and activation of innate immune signaling. Moreover, microbial hijacking strategies that inhibit Golgi-associated innate immune responses will also be discussed.

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