Journal
TRENDS IN CELL BIOLOGY
Volume 30, Issue 10, Pages 764-776Publisher
CELL PRESS
DOI: 10.1016/j.tcb.2020.07.003
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Funding
- NCI [P30 CA013696]
- NIH [R01 DK060694, F30 CA180601]
- American Cancer Society [RP-10-033-01-CCE]
- American Cancer Society-Fairfield County Comedy Against Cancer Postdoctoral Fellowship [PF-19-227-01-CMS]
- American Gastroenterology Association Bern
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Cancer cell identity and plasticity are required in transition states, such as epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET), in primary tumor initiation, progression, and metastasis. The functional roles of EMT, MET, and the partial state (referred to as pEMT) may vary based on the type of tumor, the state of dissemination, and the degree of metastatic colonization. Herein, we review EMT, MET, pEMT, and plasticity in the context of tumor metastasis.
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