Microvascular Fragments: More Than Just Natural Vascularization Units

Adipose tissue-derived microvascular fragments serve as natural vascularization units in angiogenesis research and tissue engineering due to their ability to rapidly reassemble into microvascular networks. Recent studies indicate that they exhibit additional unique properties that may be beneficial for a wide range of future biomedical applications. Their angiogenic activity can be increased during short-term cultivation as a means of adapting their vascularization capacity to patient-specific needs. Moreover, they are a source of endothelial progenitor cells, multipotent mesenchymal stromal cells, and lymphatic vessel fragments. Finally, they exert immunomodulatory effects, determining the tissue integration of implanted biomaterials. Hence, microvascular fragments represent versatile building blocks for the improvement of vascularization, organotypic tissue formation, lymphatic regeneration, and implant integration.

Automated summary

Adipose tissue-derived microvascular fragments have the ability to rapidly reassemble into microvascular networks, exhibit angiogenic activity, and serve as a source of endothelial progenitor cells and multipotent mesenchymal stromal cells. They also play a crucial role in tissue integration of implanted biomaterials.