Journal
TRENDS IN BIOTECHNOLOGY
Volume 38, Issue 12, Pages 1373-1384Publisher
CELL PRESS
DOI: 10.1016/j.tibtech.2020.04.013
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Funding
- NIH [DP1 AR068147, R01 AR063698]
- NSF/EFRI [1332329]
- National Medal of Technology and Innovation
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The secretome is defined as the set of molecules and biological factors that are secreted by cells into the extracellular space. In the past decade, secretome-based therapies have emerged as a promising approach to overcome the limitations associated with cell-based therapies for tissue and organ regeneration. Considering the growing number of recent publications related to secretome-based therapies, this review takes a step-by-step engineering approach to evaluate the role of the stem cell secretome in regenerative engineering. We discuss the functional benefits of the secretome, the techniques used to engineer the secretome and tailor its therapeutic effects, and the delivery systems and strategies that have been developed to use the secretome for tissue regeneration.
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