Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 45, Issue 10, Pages 889-905Publisher
CELL PRESS
DOI: 10.1016/j.tibs.2020.06.001
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Funding
- National Institutes of Health [R01 MH111516, R35 CA197622, R01 DK073368, R01 GM111665]
- Air Force Office of Scientific Research [FA9500-18-1-0051]
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Cell signaling networks are intricately regulated in time and space to determine the responses and fates of cells to different cues. Genetically encodable fluorescent and bioluminescent biosensors enable the direct visualization of these spatiotemporal signaling dynamics within the native biological context, and have therefore become powerful molecular tools whose unique benefits are being used to address challenging biological questions. We first review the basis of biosensor design and remark on recent technologies that are accelerating biosensor development. We then discuss a few of the latest advances in the development and application of genetically encodable fluorescent and bioluminescent biosensors that have led to scientific or technological breakthroughs.
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