Journal
TRENDS IN BIOCHEMICAL SCIENCES
Volume 45, Issue 10, Pages 829-844Publisher
CELL PRESS
DOI: 10.1016/j.tibs.2020.05.009
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Funding
- National Institute of Health [DP1 DA042078, R21 DA044767, R01 HD097088, R01 MH116900]
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Histone post-translational modifications (PTMs) have emerged as exciting mechanisms of biological regulation, impacting pathways related to cancer, immunity, brain function, and more. Over the past decade alone, several histone PTMs have been discovered, including acylation, lipidation, monoaminylation, and glycation, many of which appear to have crucial roles in nucleosome stability and transcriptional regulation. In this review, we discuss novel histone PTMs identified within the past 10 years, with an extended focus on enzymatic versus nonenzymatic mechanisms underlying modification and adduction. Furthermore, we consider how these novel histone PTMs might fit within the framework of a so-called 'histone code', emphasizing the physiological relevance of these PTMs in metabolism, development, and disease states.
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