Journal
TRANSBOUNDARY AND EMERGING DISEASES
Volume 68, Issue 2, Pages 477-486Publisher
WILEY-HINDAWI
DOI: 10.1111/tbed.13699
Keywords
African swine fever virus; animal feed; anti-infective agents; ASFV; domestic pig; food additives; ships; swine diseases; virus inactivation
Categories
Funding
- Swine Health Information Center [17-189]
- State of Kansas National Bio and Agro-defense Facility Fund
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African swine fever is a significant threat to global pork production, as the virus can be transmitted through contaminated feed. Research shows that feed additives based on medium-chain fatty acids and formaldehyde can reduce the infectivity of ASFV.
African swine fever (ASF) is currently considered the most significant global threat to pork production worldwide. Disease caused by the ASF virus (ASFV) results in high case fatality of pigs. Importantly, ASF is a trade-limiting disease with substantial implications on both global pork and agricultural feed commodities. ASFV is transmissible through natural consumption of contaminated swine feed and is broadly stable across a wide range of commonly imported feed ingredients and conditions. The objective of the current study was to investigate the efficacy of medium-chain fatty acid and formaldehyde-based feed additives in inactivating ASFV. Feed additives were tested in cell culture and in feed ingredients under a transoceanic shipment model. Both chemical additives reduced ASFV infectivity in a dose-dependent manner. This study provides evidence that chemical feed additives may potentially serve as mitigants for reducing the risk of ASFV introduction and transmission through feed.
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