Journal
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 127, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2020.115895
Keywords
Extraction scale-up; Ultrasonic-assisted extraction; Supercritical fluid extraction; Microwave-assisted extraction; Batch to flow; Bioactive compounds; Green extraction
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Funding
- Key Research and Development Program of Zhejiang Province, China [2018C02049, 2020C02040, 2020C02037]
- Technology Innovation Programme of Zhejiang Province, China [ZJWR0102001]
- China Postdoctoral Science Foundation, China [2018M642443]
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The impact of the extraction technologies on product yield and analytical profile is relevant. This review is aiming to discuss recent experiences of successes and failures in non-conventional extraction scalingup, to better understand the challenges and designing of existing and new techniques. Understanding the crucial extraction factors at laboratory and pilot scale is of paramount value for the engineering work of scaling-up. Besides, a careful analysis and modelling of heat and mass transfer and energy consumption, the design of industrial extraction plants driven by economic and environmental factors, are well covered in the present review. Current trend strongly favors scaling-up of green approaches that consumes less organic solvent(s), involves minimal operational steps, provides high throughput capability and assures highest yield at lower costs. Current and future challenges in scaling-up extraction of bioactive compounds require a parallel development of suitable analytical methods to monitor the process and ensure high yield and quality. (c) 2020 Elsevier B.V. All rights reserved.
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