Development of boronate affinity-based magnetic composites in biological analysis: Advances and future prospects

Cis-diol-containing species (CDCSs) including nucleosides, saccharides, glycoproteins/glycopeptides, cell and bacteria, etc., have been recognized as major targets in various research frontiers, such as environment and food analysis, biological omics and bioanalysis. Highly efficient separation and enrichment of CDCSs from biosample matrixes is a prerequisite. In recent years, boronate affinity materials serve as adsorbents for CDCSs have drawn immense attention in various applications. Coupled with engineered magnetic composites, boronate affinity-based magnetic composites (BAMCs) hold great potential in application owing to their unique properties. The purpose of this review is to depict the state-of the art development of exploiting BAMCs as adsorbents for the selective enrichment of CDCSs. For the sake of clarification, the fundamental development of BAMCs, as well as their application, were concluded. Particularly, the effects of fabrication strategies on the performance of BAMCs have been discussed. In addition, the review also covers the application of BAMCs in bioanalysis. (C) 2020 Elsevier B.V. All rights reserved.