Journal
TOXIN REVIEWS
Volume 40, Issue 4, Pages 886-900Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15569543.2020.1799408
Keywords
Cytotoxin; Naja sumatrana; apoptosis; caspase; mitochondrial depolarization; LDH; HMGB1
Categories
Funding
- Fundamental Research Grant Scheme [FRGS/1/2018/SKK08/MUSM/03/1]
- Ministry of Education Malaysia
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The study found that sumaCTX induces cytotoxicity in breast cancer cells, leading to apoptosis rather than necrosis, and its cytotoxicity is a concentration-dependent process.
The mechanism ofsuma-cytotoxin (sumaCTX)-induced cytotoxicity is poorly understood, especially in the transition of cell death pattern. This study examines its cytotoxicity, caspase-3/7 activity, mitochondrial functions, and occurrence of apoptosis. ThesumaCTX triggered cytotoxicity in MCF-7 cells before 24 h, with activation of caspase-3/7 and mitochondrial depolarization, followed by a substantial percentage of AV(+)apoptotic cells. The absence of HMGB1 suggested apoptosis was the profound cell death independent of its membrane perturbing effect, without transitioning into necrosis. Its cytotoxicity was a concentration-dependent but not time-dependent process. The findings provide valuable insight into mechanisms ofsumaCTX-induced cytotoxicity in breast cancer cells.
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