4.6 Article

Melatonin alleviates defects induced by zearalenone during porcine embryo development

Journal

THERIOGENOLOGY
Volume 151, Issue -, Pages 66-73

Publisher

ELSEVIER SCIENCE INC
DOI: 10.1016/j.theriogenology.2020.04.005

Keywords

Zearalenone; Melatonin; Porcine; Embryonic development

Funding

  1. Next-Generation BioGreen 21 Program [PJ01322101]
  2. Basic Science Research Program through the National Research Foundation of Korea [2018R1A2B2005880]
  3. Rural Development Administration, Republic of Korea
  4. National Research Foundation of Korea [2018R1A2B2005880] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

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Zearalenone (ZEA), which is produced by several fusarium mycotoxins, is found in animal feed and food products, and can exert estrogen-like activity. Melatonin (MT) is emerging as a supplement that can fight the toxic effects of mycotoxins. With a variety of physiological functions that play crucial roles in the development of animal germ cells and embryos, melatonin regulates circadian rhythms and has an anti-inflammatory and anti-oxidative role. This study investigated the protective effects of melatonin against ZEA in porcine early embryonic development. Our results showed that ZEA adversely affected this development, while melatonin supplementation ameliorated the toxic effects. ZEA exposure increased oxidative stress and impaired mitochondrial function, which may affect blastocyst formation. Moreover, we found that ZEA exposure promotes apoptosis, DNA damage, and autophagy in porcine blastocysts. The toxic effects of ZEA on early embryos may be the result of oxidative stress-mediated early apoptosis, while melatonin treatment significantly improved these phenotypes in ZEA-exposed porcine early embryos. Taken together, our results indicate that melatonin has a protective effect on defects caused by ZEA during early porcine embryonic development. (C) 2020 Published by Elsevier Inc.

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