Journal
TETRAHEDRON LETTERS
Volume 61, Issue 23, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2020.151940
Keywords
Cobalt-or copper-catalyzed; gem-difluoroallyl MIDA boronates; alpha-trifluoromethyl alkenes
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Funding
- National Key Research and Development Program of China [2017YFD0200505]
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A novel two-step synthesis of gem-difluoroallyl MIDA boronates, which are air- and moisture-stable fluorine-containing building blocks for potential applications in iterative cross-couplings, was developed. The first step involves cobalt- or copper-catalyzed defluoroborylation of alpha-trifluoromethyl alkenes with B(2)pin(2) in the absence of ligand. Next, without further purification, the resulting gem-difluroallylboronic acid pinacol ester was converted to gem-difluoroallyl MIDA boronates by heating in the presence of MIDA. (C) 2020 Elsevier Ltd. All rights reserved.
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