Journal
TALANTA
Volume 222, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.talanta.2020.121534
Keywords
COVID-19; SARS-CoV-2; Diagnostic kits; Sensors/biosensors; Response strategies
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This review critically examines the current developed diagnostic tools in response to the COVID-19 pandemic, comparing different types such as nucleic acid detection tests, antibody and protein-based diagnosis tests. The discussion also includes potential technologies under development, as well as the role of data collection and epidemiological analysis in emerging technologies.
As COVID-19 has reached pandemic status and the number of cases continues to grow, widespread availability of diagnostic testing is critical in helping identify and control the emergence of this rapidly spreading and serious illness. However, a lacking in making a quick reaction to the threat and starting early development of diagnostic sensing tools has had an important impact globally. In this regard, here we will review critically the current developed diagnostic tools in response to the COVID-19 pandemic and compare the different types through the discussion of their pros and cons such as nucleic acid detection tests (including PCR and CRISPR), antibody and protein-based diagnosis tests. In addition, potential technologies that are under development such as on-site diagnosis platforms, lateral flow, and portable PCR units are discussed. Data collection and epidemiological analysis could also be an interesting factor to incorporate with the emerging technologies especially with the wide access to smartphones. Lastly, a SWOT analysis and perspectives on how the development of novel sensory platforms should be treated by the different decision-makers are analyzed.
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