Synthesis, identification and molecular docking studies ofN-functionalized piperidine derivatives linked to 1,2,3-triazole ring

New derivatives of piperidine bearing a 1,2,3-triazole ring designed and synthesized smoothly over six steps fromN-protected piperidone-4-one. These steps included reduction of the carbonyl group/tosylation of the resulting alcohol providing tosyl derivative in a good yield, followed by nucleophilic substitution and Cu-catalysed azide-alkyne cycloaddition. By removing the protecting group and functionalizing amine groupviareductive amination gave the desired design in moderate to very good yields. Molecular modeling studies of these compounds predicted possible binding modes into the active site of dopamine receptor D2.