Remote Deprotometalation-Iodolysis ofN,N-Diisopropyl-2-trimethylsilylferrocenecarboxamide: A New Route Toward 1,1′-Disubstituted Ferrocenes

The 1,1 '-disubstitution is currently the most frequent substitution pattern encountered in the ferrocene series. Here an original access based on the remote deprotometalation ofN,N-diisopropyl-2-trimethylsilylferrocenecarboxamide is reported. The key intermediate, 1 '-iodo-N,N-diisopropylferrocenecarboxamide, was prepared in multiple grams and was further functionalized toward fifteen 1 '-substituted iodoferrocenes.