Journal
SURGICAL CLINICS OF NORTH AMERICA
Volume 100, Issue 4, Pages 681-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.suc.2020.05.001
Keywords
Chronic wound; Ulcer; Biofilm; Bacteria; Inflammation; Proteases; Cytokines; Wound healing
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Chronic wounds present a unique therapeutic challenge to heal. Chronic wounds are colonized with bacteria and the presence of a biofilm that further inhibits the normal wound healing processes, and are locked into a very damaging proinflammatory response. The treatment of chronic wounds requires a coordinated approach, including debridement of devitalized tissue, minimizing bacteria and biofilm, control of inflammation, and the use of specialized dressings to address the specific aspects of the particular nonhealing ulcer.
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