Journal
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
Volume 235, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.saa.2020.118262
Keywords
Microfluidic; Surface-enhanced Raman scattering; Silver dendrite; Sensitivity; Amoxicillin
Categories
Funding
- National Key Research and Development Program [2016YFC1100704, 2016YFC1102203, 2017YFC0108505]
- Fundamental Research Funds for the Central Universities [YWF-19-BJ-J-203]
- Science, Technology and Innovation Commission of Shenzhen Municipality [JCYJ20180307123641888]
- NSFC [81970900, 31971238, 11827803, 11421202, 61227902, 31470901]
- Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Fund [ZYLX201508]
- Capital Health Research and Development of Special Fund [2014-1-2091]
- 111 Project of China [B13003]
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A high sensitive surface-enhanced Raman scattering (SERS) substrate based on the Ag dendrite in a T-type microfluidic device was constructed by a simple and rapid strategy. According to the simulated results by COMSOL Multiphysics, the microfluidic-SERS sensor was fabricated by simultaneously introducing into 40 mmol.L-1 silver nitrate solution and 0.2 mol.L-1 sodium nitrate solution for about 15 min with the flow velocity at 20 mu L.min(-1) at room temperature, respectively. The analytical performance of this sensor was investigated with different concentrations of amoxicillin aqueous solution, and the detection limit was up to 1.0 ng.mL(-1). And the semi-quantitation was obtained from the relationship between the Raman intensity and the logarithm of the amoxicillin concentration. This method can be employed to fabricate high sensitive microfluidic-SERS sensors as well as realize many lab-on-a-chip applications with the integration of other microfluidic networks. (C) 2020 Elsevier B.V. All rights reserved.
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