Journal
SMALL
Volume 16, Issue 31, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202002343
Keywords
glucose detection; hydrogel colorimetric biosensors; peroxidase-like activity; single iron site nanozymes
Categories
Funding
- National Key R&D Program of China 2017YFA [0208300, 0700104]
- Postdoctoral Science Foundation of China [2019M653052]
- National Natural Science Foundation of China [21671180]
Ask authors/readers for more resources
Nanomaterials with enzyme-mimicking characteristics have engaged great awareness in various fields owing to their comparative low cost, high stability, and large-scale preparation. However, the wide application of nanozymes is seriously restricted by the relatively low catalytic activity and poor specificity, primarily because of the inhomogeneous catalytic sites and unclear catalytic mechanisms. Herein, a support-sacrificed strategy is demonstrated to prepare a single iron site nanozyme (Fe SSN) dispersed on the porous N-doped carbon. With well-defined coordination structure and high density of active sites, the Fe SSN performs prominent peroxidase-like activity by efficiently activating H(2)O(2)into hydroxyl radical (center dot OH) species. Furthermore, the Fe SSN is applied in colorimetric detection of glucose through a multienzyme biocatalytic cascade platform. Moreover, a low-cost integrated agarose-based hydrogel colorimetric biosensor is designed and successfully achieves the visualization evaluation and quantitative detection of glucose. This work expands the application of single-site catalysts in the fields of nanozyme-based biosensors and personal biomedical diagnosis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available