Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 100, Issue 5, Pages 489-499Publisher
WILEY
DOI: 10.1002/cpt.442
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Funding
- National Institutes of Health [GM066233]
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Plasma membrane monoamine transporter (PMAT) is a new polyspecific organic cation transporter that transports a variety of biogenic amines and xenobiotic cations. Highly expressed in the brain, PMAT represents a major uptake(2) transporter for monoamine neurotransmitters. At the blood-cerebrospinal fluid (CSF) barrier, PMAT is the principal organic cation transporter for removing neurotoxins and drugs from the CSF. Here I summarize our latest understanding of PMAT and its roles in monoamine uptake and xenobiotic disposition.
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